Columbus then sits down, unintentionally defecating in his pants due to his Irritable Bowel Syndrome. Seeing it's not dead, he shoots it in the head. He slams on the brakes, sending it through the windshield into a flower shop, while he is safe thanks to his seat-belt. The moment he relaxes, he notices a zombie in his rear-mirror which had somehow climbed into the car while he was running. After a second lap around the parking lot, Columbus discovers that his car is unlocked, gets in, and drives off, leaving the zombies behind. As he considers this, a zombie bursts out of the door and gives chase a second one then also appears from nowhere and joins the other zombie in chasing Columbus.
Columbus is attempting to find a restroom at a Gas 'N Gulp, but finds a bloody fingerprint on the door. The narrator, revealed to be a college-age kid named Columbus, explains that a virus mutated from Mad Cow Disease into "mad zombie" disease, making people extremely violent and with a bad case of the munchies, destroying their ability to feel pain and their intelligence in the process. Two months later, America has fallen into ruins.
A narrator explains that zombies have appeared in the world and that he has survived by following rules to ensure his safety - amongst them are staying in shape, wearing a seat belt, and giving a second shot to the head when facing a zombie to ensure it won't get back up. Unable to outrun him, the man falls victim. with an overturned limo as a man picks up a camera and runs for his life from a secret service agent that has been infected. The movie begins with a shot of now-destroyed Washington D.C.